| 英文品名 |
cantuzumab mertansine |
| 名称来源 |
p-INNList-89,2003;r-INNList-51,2004; |
| 别 名 |
SB-408075，huC242-DM1 |
| 化学表述 |
immunoglobulin G1, anti-(mucin CanAg) (human-mouse monoclonal C242 heavy chain), disulfide with human-mouse monoclonal C242 light chain, dimer, conjugate at the 6-amino groups of four lysine residues forming an amide bond with (4RS)-4-[(3-{[(1S)-2-{[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy}-1-methyl-2-oxoethyl]methylamino}-3-oxopropyl)disulfanyl]pentanoyl groups |
| CA登记号 |
400010-39-1 |
| 结 构 式 |
|
| 品种类别 |
抗肿瘤药>单克隆抗体类; treatment of tumors that express C242 antigen; |
| 简介 |
上市（SmithKline Beecham, Chemsyn Laboratories,Unisyn Technologies, and ImmunoGen, Inc.，美国）。Treatment of colorectal cancer, pancreatic cancer and other solid tumor types that express the C242 antigen. |
|
